Transdermal Gels
PLO gel (Pluronic Lecithin Organogel) is a transdermal vehicle created by compounding pharmacists to administer medications through the skin when other methods are not practical. Extensive research confirms that these gels allow medication to be absorbed through the skin for almost immediate effects. Many medications can be formulated with a transdermal PLO base.
Transdermal PLO gels can be formulated to contain SINGLE AGENTS or COMBINATIONS of ingredients that provide quick and long-lasting relief with minimal unwanted side effects. PLO disrupts the lipid layers of the stratum corneum without damaging the skin. This allows the medication to diffuse through the stratum corneum into the dermal-epidermal blood flow.
The site of application can drastically affect the distribution and absorption of a drug. If a systemic effect is desired, the gel should be applied to neck, inner thigh, or inner wrist area. For a local effect, the gel should be applied directly to the joint or painful region and then rubbed in well.
For better results, MOST PHYSICIANS PRESCRIBE MULTI-INGREDIENT TRANSDERMAL PLO GELS that combine complementary components to produce synergistic effects. For example, an anti inflamatory + muscle relaxer + local anesthetic + neuropathic agent = a treatment for severe neuropathic pain.
Dispensing
PLO gels come in the following sizes:- 1 ounce (30 grams) plastic ointment tube
- 2 ounce (60 grams) plastic ointment tube
- 4 ounce (120 grams) plastic ointment tube
Administration
PLO gels are typically applied 4 times a day in the following manner:- Moisten the skin in the treatment area.
- Apply cream sparingly and massage in well.
Storage
Transdermal PLO gels should be stored at a controlled room temperature. NEVER IN THE REFRIGERATOR.